Basic Information
VIS ID
TVIS44015784
Fusion event
HTLV-1-ARL6IP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
153616524/152760010 (Hg38)
End
153616524/152760010 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA2S
Target gene
ARL6IP6
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-181a-5p ; hsa-let-7a-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-4427 ; hsa-mir-3140-5p ; hsa-mir-4301 ; hsa-mir-664a-3p ; hsa-mir-596 ; hsa-mir-4293 ; hsa-mir-374c-3p ; hsa-mir-4760-3p ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-3941 ; hsa-mir-205-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-32-3p
Nearest miRNA
hsa-mir-128-1/Upstream/1391599; hsa-mir-10b/Downstream/6426825;
Nearest TSS
ENST00000437798/Upstream/39843; ENST00000429916/Downstream/441716;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/40971, chr2-CpG: 88/Downstream/717925
Upstream sequence
CTGTCTACTCAGAAGACTGAGAAACCTGCTGTTCATTATGTAGTTCAGATATTTATCACAATCATCCTCATTATGGAAGACCTTTTAAAGCATTGTTTTA
Downstream sequence
GAATGTCTGAGTATTAAGATACAGATTAATTGGGAATATCTGAGTATTAAGTACTTTCTTCAGAGTATAAGATGTTTACCTCATCTTTTTACTTTTGTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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