Basic Information
VIS ID
TVIS44015801
Fusion event
HTLV-1-AGPS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
178275522/177410794 (Hg38)
End
178275522/177410794 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
AGPS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-4709-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4635 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-190a-3p ; hsa-mir-5689 ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-8485 ; hsa-mir-4643 ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-494-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-335-3p ; hsa-mir-3978 ; hsa-mir-6516-3p ; hsa-mir-4261 ; hsa-mir-3613-3p ; hsa-mir-1825
Nearest miRNA
hsa-mir-10b/Upstream/96912; hsa-mir-1244-1/Downstream/2450042;
Nearest TSS
ENST00000437798/Upstream/18026; ENST00000460342/Downstream/9475;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/17630, chr2-CpG: 61/Downstream/141773
Upstream sequence
aagactgagaaggccacaccagtgtccaggagacagttaacctcctggccctcaatggtcaagcatacccggggctctgtgagggtgacggcatgggctg
Downstream sequence
gcgcttaccccaggcaccctcagtcctgctgctggatcatctggttagtggcttctgactcagagatccttcatcccctggggcagtgggccttccagtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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