Basic Information
VIS ID
TVIS44015810
Fusion event
HTLV-1-WDR75 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
190338746/189474020 (Hg38)
End
190338746/189474020 (Hg38)
Orient
+
Location type
Intronic
Target gene
WDR75
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-3119 ; hsa-mir-552-5p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-627-3p ; hsa-mir-6506-3p ; hsa-mir-4762-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-1228-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-7977 ; hsa-mir-30c-1-3p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4726-3p ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-10b/Upstream/340909; hsa-mir-1244-1/Downstream/17309214;
Nearest TSS
ENST00000437798/Upstream/11536; ENST00000605941/Downstream/106721;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/32313, chr2-CpG: 68/Downstream/106713
Upstream sequence
tgtcatttttgtgggatttggtgaagaagcagtggtaaatgcatgtattattctgtcatctAAGTGTTCACTGTTAGCTCTTCTCATAAGTGGGATGcta
Downstream sequence
ggcctcagttgctttctctgtgaaatgagaggatcatactaactggataatttgtaaaattcctttcatcccagactttttatgattctgtAGTACTTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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