Basic Information
VIS ID
TVIS44015831
Fusion event
HTLV-1-SPEG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
220329038/219464316 (Hg38)
End
220329038/219464316 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPEG
Nearest miRNA
hsa-mir-10b/Upstream/170116; hsa-mir-1244-1/Downstream/84757;
Nearest TSS
ENST00000437798/Upstream/2931; ENST00000485069/Downstream/7346;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/14944, chr2-CpG: 136/Downstream/19250
Upstream sequence
GAAGTGACCTGGAAGCTCCTAGAGGTGGGTGGGATGGCAGAGTGGGGGTAAAAACCTAGCCCTGGAAACCAGGGATGCCCACGGTCAGTGGGACAGATCT
Downstream sequence
GGGGACTGGGCAAACTGCACAGGGAAGGAGAGGCCTGCACAGTGCTGCAGCCCCAGTTCCTGTGCACGCACATCAGGCCCCTGGGCCCTGGGACTGAGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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