Basic Information
VIS ID
TVIS44015832
Fusion event
HTLV-1-STK11IP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
220466826/219602104 (Hg38)
End
220466826/219602104 (Hg38)
Orient
-
Location type
Intronic
Target gene
STK11IP
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-3148 ; hsa-mir-4251 ; hsa-mir-548az-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-539-5p ; hsa-mir-4324 ; hsa-mir-5193 ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-10b/Upstream/52957; hsa-mir-1244-1/Downstream/304398;
Nearest TSS
ENST00000437798/Upstream/3661; ENST00000465230/Downstream/3403;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3882, chr2-CpG: 85/Downstream/25279
Upstream sequence
CCACTGTCTGCATGGCCTCCGAGGCATCTACTCCCAGCTGGAGACCCTGATTTGCAGCAGGAGCCTCCAGGCATTAGAGGTAAGGAGAGTGAGGGGTGAG
Downstream sequence
CTCAGACACCTCAACTTGAGAGATGTAGaagaccaagctctgatgttctcccctctctgcagctctccctgcctcctgcttccctctagacagtgtcctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate