Basic Information
VIS ID
TVIS44015837
Fusion event
HTLV-1-COL4A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
228042956/227178240 (Hg38)
End
228042956/227178240 (Hg38)
Orient
+
Location type
Intronic
Target gene
COL4A3
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548c-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10b/Upstream/519447; hsa-mir-1244-1/Downstream/293892;
Nearest TSS
ENST00000437798/Upstream/13675; ENST00000487633/Downstream/80958;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/13779, chr2-CpG: 65/Downstream/146880
Upstream sequence
agggcaaaaagttcactgtattacccaggcctaggagttcaagatcagcctgggtaatacaatgtgacctctctctaccaaaaatttaaaaattagccgg
Downstream sequence
gcatggtggcatgtgcctgcagtctcagctactcaggaggctgaggtgggaggatcgcttgagccctgcagagtggaggctacagcgagctgacagcaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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