Basic Information
VIS ID
TVIS44015850
Fusion event
HTLV-1-ESPNL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
239015714/238107073 (Hg38)
End
239015714/238107073 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
ESPNL
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-10b/Upstream/596085; hsa-mir-149/Downstream/961744;
Nearest TSS
ENST00000437798/Upstream/6653; ENST00000423032/Downstream/813;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/6353, chr2-CpG: 21/Downstream/21643
Upstream sequence
CGACGGGCTGCTGGCGGCTCTGCTGTTCTCGTGGCCTCCCCAGTGGGGAAAGCGGGCACACTCAAGGCAGGAAGGAGGGTGAAGGCGGGGAGCCAGCACG
Downstream sequence
CCCATCACCCGTCTGTCAGGAAGGCAGGCTGTCCTAGGAGACCCCCGCGTCCCACTGGCAGGCCCAGGCCCCATGTCTGTCCCAGCTGCACAGGTTTCCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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