Basic Information
VIS ID
TVIS44015851
Fusion event
HTLV-1-ATAD2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
24078505/23855635 (Hg38)
End
24078505/23855635 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATAD2B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-4529-3p ; hsa-mir-8058 ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-150-5p ; hsa-mir-186-3p
Nearest miRNA
hsa-mir-3125/Upstream/4507130; hsa-mir-10b/Downstream/1473005;
Nearest TSS
ENST00000437798/Upstream/23024; ENST00000479859/Downstream/12252;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/164936, chr2-CpG: 113/Downstream/70751
Upstream sequence
taccttagaaacttaaacacacatttaccataggctccagaaattcctctctcagggatttacccaacagaaaagaaaacatgtccacacaaaaacttgt
Downstream sequence
aGAGAcgctttgagaggccaagatggagggctcgcttgagactaggtgtcagaaaccaaccagggaaacatagcgagactccgtctctacaacaaataca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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