Basic Information
VIS ID
TVIS44015863
Fusion event
HTLV-1-MAPRE3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
27248794/27025926 (Hg38)
End
27248794/27025926 (Hg38)
Orient
-
Location type
Exonic
Target gene
MAPRE3
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-3133 ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4428 ; hsa-mir-4773 ; hsa-mir-4708-3p ; hsa-mir-4712-5p ; hsa-mir-770-5p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-1301/Upstream/1697205; hsa-mir-10b/Downstream/970441;
Nearest TSS
ENST00000437798/Upstream/11127; ENST00000478980/Downstream/6984;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/54930, chr2-CpG: 46/Downstream/6806
Upstream sequence
GGGGAACCTGAGGTGGGGACCTCTGGCTTGAACATCACTTTGTCCCCAAGCAGCTGGTGGACTTGAAGCTGACAGTGGATGGGCTGGAGAAGGAACGTGA
Downstream sequence
CTTCTACTTCAGCAAACTTCGTGACATCGAGCTCATCTGCCAGGAGCATGAAAGTGAAAACAGCCCTGTTATCTCAGGCATCATTGGCATCCTCTATGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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