Basic Information
VIS ID
TVIS44015868
Fusion event
HTLV-1-ALK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
30124967/29902101 (Hg38)
End
30124967/29902101 (Hg38)
Orient
+
Location type
Intronic
Target gene
ALK
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-96-5p
Nearest miRNA
hsa-mir-1301/Upstream/1905652; hsa-mir-10b/Downstream/2630052;
Nearest TSS
ENST00000437798/Upstream/2504; ENST00000482474/Downstream/19465;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/786058, chr2-CpG: 147/Downstream/17864
Nearest cancer related gene
ALK(OG, No orient, 0)
Upstream sequence
TTTTCATTTCTCTTATCTTCCAAAAAGACATGAAATTAAGTTCTAAGCAAAGCACATAATTTATGAGAAGtctctgtgctgatgactcccaaatccccat
Downstream sequence
gcccagccctgacttcttacatgagttctagtgccatgtttccagctagcaggacacagctgcttggagttgggctatcatctcggctccccaggtgcaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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