Basic Information
VIS ID
TVIS44015881
Fusion event
HTLV-1-PREPL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
44588375/44361236 (Hg38)
End
44588375/44361236 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PREPL
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-125a-5p ; hsa-mir-6079 ; hsa-mir-633 ; hsa-mir-3166 ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-5000-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1301/Upstream/8889750; hsa-mir-10b/Downstream/3016439;
Nearest TSS
ENST00000437798/Upstream/562; ENST00000477623/Downstream/257;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/191746, chr2-CpG: 30/Downstream/579
Upstream sequence
CAAGGCTAGGATGGGGGTGGGGTAGATAAATGGGTGTTCTCAGGAGAACCTATTCGTTTACCCCGTGCAACTCTCCACCCCAGGGATGAGGCGATCTGAA
Downstream sequence
TGCAACAGGGAGAGGGACCAGGTGACACGCACGCAGTGCCGGGACATTAGTCAAAAAGCGAGGACCTGGGGACTGAGGGGTGGGTGGCTGGGCGGGGGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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