Basic Information
VIS ID
TVIS44015896
Fusion event
HTLV-1-CFAP36 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
55748333/55521197 (Hg38)
End
55748333/55521197 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CFAP36
miRNAs that regulate target gene
hsa-mir-1301-3p
Nearest miRNA
hsa-mir-1301/Upstream/1671992; hsa-mir-10b/Downstream/461770;
Nearest TSS
ENST00000437798/Upstream/1466; ENST00000490934/Downstream/9814;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1334, chr2-CpG: 79/Downstream/95934
Upstream sequence
TTTCATTGCTATAATCAATATTCAAATCGTAGTTATTAAAGTGTTATTTTTACAGGTAATTTTTTAACAATGTTCAAAAACAAAATAACTTGTATTTGTA
Downstream sequence
CTCCttttttttttttttttttgggagacagagtgtcgctctgttgcccaggctggagtgcagtggcgtgatcttggctcactgcaTTGTTTTATACATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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