Basic Information
VIS ID
TVIS44015914
Fusion event
HTLV-1-ARHGAP25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
68948866/68721734 (Hg38)
End
68948866/68721734 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ARHGAP25
Nearest miRNA
hsa-mir-1301/Upstream/2363406; hsa-mir-10b/Downstream/381948;
Nearest TSS
ENST00000437798/Upstream/41772; ENST00000463061/Downstream/13101;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/66292, chr2-CpG: 84/Downstream/291217
Nearby gene
ARHGAP25(+13047) ;
Upstream sequence
AGTGAAATCAGCTGCTCTAGTTATTTCCTGTTCTGGCAGCACCCTGCTGAGCATCTCGTGATTTCAGGAGAGTAGAAGCTGGGTGGTGGAGCAGTCCAGG
Downstream sequence
TTTGTCTTAAAAATACAGTTCTCCAGCTGTTGTATTGGATTTCCTCTCACAGAAACCTAAGGTCGACAGAGGATTACAAATTTGCCTTTCCATAACTTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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