Basic Information
VIS ID
TVIS44015924
Fusion event
HTLV-1-EXOC6B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
72761487/72534358 (Hg38)
End
72761487/72534358 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
EXOC6B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-25-3p ; hsa-mir-7977 ; hsa-mir-6516-3p ; hsa-mir-6849-3p ; hsa-mir-5588-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/2281353; hsa-mir-10b/Downstream/2556454;
Nearest TSS
ENST00000437798/Upstream/18604; ENST00000498749/Downstream/291647;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/384312, chr2-CpG: 63/Downstream/291150
Upstream sequence
TTTTCTAGTTTTGTACTTTCAAGAACTGCTTGAGGAGGAGATAGATATAGCACTAAAAATTAAACTACATCCTCAGGGCGTGCCATGCTCATAAAGAATA
Downstream sequence
TTTCACAAAGGCCACAGGGGATAAGTACTTTGAATTTATATTGAAAAAACAGAAGAAGAGTGAAATAATCTATGTTTCAGGTTTAAAAGGCATACAGTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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