Basic Information
VIS ID
TVIS44015941
Fusion event
HTLV-1-TCF7L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
85531993/85304870 (Hg38)
End
85531993/85304870 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
TCF7L1
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-200b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/5438287; hsa-mir-10b/Downstream/478730;
Nearest TSS
ENST00000437798/Upstream/1477; ENST00000462396/Downstream/23115;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/169400, chr2-CpG: 96/Downstream/22141
Upstream sequence
caccatcgtaaagtcaaaatatcctaagtcACGGACTGTCTGTATATCACACTGAAGCTAGGGACTGGGAGAAGATGAATTTTTCCTGAAATGATGTCAG
Downstream sequence
GAGAGGAGACGGTGAAAGGGGATTTCTGTCTCAGGGACCAGCTCTACCTGACAGTGGAACCTCTGAGGACAGAGGAAAGCTGCCCACAGCCTAAGCCCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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