Basic Information
VIS ID
TVIS44015942
Fusion event
HTLV-1-POLR1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86330786/86103663 (Hg38)
End
86330786/86103663 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
POLR1A
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-587 ; hsa-mir-5581-3p ; hsa-mir-4716-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-1236-3p ; hsa-mir-1827 ; hsa-mir-203b-3p ; hsa-mir-2467-3p ; hsa-mir-3158-5p ; hsa-mir-3670 ; hsa-mir-3678-3p ; hsa-mir-3679-3p ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4663 ; hsa-mir-4680-5p ; hsa-mir-4722-5p ; hsa-mir-4753-5p ; hsa-mir-4768-3p ; hsa-mir-485-5p ; hsa-mir-6808-5p ; hsa-mir-6884-5p ; hsa-mir-6893-5p ; hsa-mir-7158-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-1285-2/Upstream/319986; hsa-mir-10b/Downstream/89363;
Nearest TSS
ENST00000437798/Upstream/37949; ENST00000473829/Downstream/2210;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/214459, chr2-CpG: 67/Downstream/1873
Upstream sequence
ACACTTCTGCTTTTGGATGAAATCGTATCCACTTATGGCAGTGATGATATAATTGGAATTTCTGGGCTAGCACACTGTTACCAATGATACCAGAGCTGTG
Downstream sequence
GCTCAGGAGTTTATTCATCCATTTATTCAGACTTGAGGATAAAAGACAAGAGTGACACATATAAGAAGCTCAAGGATAGTGGAGGAAGACAAATATACAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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