Basic Information
VIS ID
TVIS44015943
Fusion event
HTLV-1-RNF103 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86835266/86608143 (Hg38)
End
86835266/86608143 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
RNF103
miRNAs that regulate target gene
hsa-mir-320b ; hsa-mir-320a ; hsa-mir-21-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/415035; hsa-mir-10b/Downstream/586643;
Nearest TSS
ENST00000437798/Upstream/3853; ENST00000466417/Downstream/6556;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/44624, chr2-CpG: 133/Downstream/14776
Upstream sequence
ATCTGAACAAATTCAATGACAATACCATGAAAATATCCTCTAGTTTTTAAACTAAACCTTTTGAGTTCTCTTAGAGAATTTTAAGACTAAAAACGATAGG
Downstream sequence
AAATATGCCTTGTGAGTTTTGGTCTTCCAGTTGCTGATGTGGCATGCTATATTTAAGAAGAAgcagggctcagtggctcacacctgtaatcccagcactt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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