Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene101914798101779202101827392101827991101861022101845524101864678101825605101830571101809001101810917101813967101815726101821518101823146101842106101843437101800871101802192101836725101838000101823793101824998101831001101831600101818201101818600101803297101803526101819957101820106101847000
Basic Information
VIS ID
TVIS44015958
Fusion event
HTLV-1-NFKBIZ integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
101565844/101847000 (Hg38)
End
101565844/101847000 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFKBIZ
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-193b-3p
Nearest miRNA
hsa-let-7g/Upstream/1882602; hsa-mir-12124/Downstream/1677033;
Nearest TSS
ENST00000440867/Upstream/19007; ENST00000486444/Downstream/2514;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/67196, chr3-CpG: 136/Downstream/1911
Upstream sequence
gcagttctaggtcaagcctgaaggcctgagaaccaggtgagctggtggtgtaagtcctagtcagagtctgaaggcccaagaaccaggagtgctgatgtct
Downstream sequence
aagggtaggaaaggatggatgtcccagctcaagaagatagcttcaggctttttgttctattctggccctcagtggattgcagaatgcctgcccgcattgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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