Basic Information
VIS ID
TVIS44015961
Fusion event
HTLV-1-ZPLD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
102174771/102455927 (Hg38)
End
102174771/102455927 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZPLD1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-let-7g/Upstream/2491529; hsa-mir-12124/Downstream/1068106;
Nearest TSS
ENST00000440867/Upstream/20894; ENST00000470756/Downstream/217986;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/605725, chr3-CpG: 32/Downstream/2897758
Upstream sequence
CCTGGAGATATGAAGCTAAAGGGAAAAGGATCATATTAACAGGGTTTTTTTCAGCCATGCCAGAGAATTTTGGCTTCATCCATGAGTGTTTTCAAATTAC
Downstream sequence
TTATTGTAACCCTTCGAACCTATAATCTCCTTTCTTTTTTATAAAGTATGAGTAAAGTGTCTTTGGTAAATATGAAGTTTCATTTACTTACATGTCACTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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