Basic Information
VIS ID
TVIS44015970
Fusion event
HTLV-1-GUCA1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
108658100/108939253 (Hg38)
End
108658100/108939253 (Hg38)
Orient
-
Location type
Intronic
Target gene
GUCA1C
Nearest miRNA
hsa-let-7g/Upstream/5415137; hsa-mir-12124/Downstream/663575;
Nearest TSS
ENST00000440867/Upstream/116394; ENST00000480826/Downstream/14509;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/349496, chr3-CpG: 28/Downstream/178695
Upstream sequence
TCACCCTTATTCAATCAGCCTTTCTCCTACAAGTGTTTCATTTCCCTTTTAAGAGCCTGGATCCTTGCTCCTTAATGAATAGAAGAGGTGAGTTGAGAAT
Downstream sequence
GTAGAAAATGGCAGAATTTGATGGTGGGATGGATGGTTATATAACTGTTAATATATTACTTGCTTCAAGGCtttttttttttttttttttttttttgaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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