Basic Information
VIS ID
TVIS44015985
Fusion event
HTLV-1-HEG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
124725632/125006788 (Hg38)
End
124725632/125006788 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEG1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-129-5p ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557
Nearest miRNA
hsa-let-7g/Upstream/274272; hsa-mir-12124/Downstream/144677;
Nearest TSS
ENST00000440867/Upstream/4768; ENST00000610060/Downstream/3761;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/118906, chr3-CpG: 114/Downstream/48614
Upstream sequence
CAGCATGCTCTAATTTGCATGTTCCTCTGATGTTTATGAACAATGAAGCTAAATGACTTGAAAAGGGAAAGATGATTGTGAAGGCGATAGTGCTGCTCTC
Downstream sequence
CTCCTGAGCTGTGCTACCTGTGGAACCCTCTGCACGCAGGCTTCCAGAACAATGGTCCTGCTTCTTCACTTTCTCATCTCACGTGTCTAGGCTGATACCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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