Basic Information
VIS ID
TVIS44015986
Fusion event
HTLV-1-SLC12A8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
124853864/125135020 (Hg38)
End
124853864/125135020 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC12A8
miRNAs that regulate target gene
hsa-mir-1227-3p ; hsa-mir-2467-3p ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-425-3p ; hsa-mir-4257 ; hsa-mir-455-3p ; hsa-mir-4680-5p ; hsa-mir-550b-2-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6807-5p ; hsa-mir-6828-5p
Nearest miRNA
hsa-let-7g/Upstream/402504; hsa-mir-12124/Downstream/16445;
Nearest TSS
ENST00000440867/Upstream/9041; ENST00000610060/Downstream/16195;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/78835, chr3-CpG: 51/Downstream/6690
Upstream sequence
CTCTCTTCATTAAGAGTCTGTTCCCTGGGGACAAGCCCAGTCACTAGCAAATGTTATTTTTTATGGAGCATCTGGTCAACATGTTAGCTTATTGCCTTCC
Downstream sequence
AGGCCAGGGACCCAAGCATGGGGCAGGAGCCCTACAGGGACCTTGGCTGTGGGAGGCTCCTCTACAGTCACTGCAGAGCAGGAACTTGGGGAAGGGAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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