Basic Information
VIS ID
TVIS44015987
Fusion event
HTLV-1-MKRN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
12611735/12570236 (Hg38)
End
12611735/12570236 (Hg38)
Orient
+
Location type
Exonic
Target gene
MKRN2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-let-7b-5p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p
Nearest miRNA
hsa-mir-12127/Upstream/2175674; hsa-let-7g/Downstream/2926003;
Nearest TSS
ENST00000440867/Upstream/9177; ENST00000626378/Downstream/15669;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12684, chr3-CpG: 89/Downstream/93324
Upstream sequence
CTCCCCAGCTTTCCACAGTCCTCACCCTCCTTCCGAGGTCACTGCATCCATTGTGAAAACTAACTCACATGAACCCGGAAAGCGTGAAAAGAGAACATTG
Downstream sequence
GTTCTTAGAGACCGAAGTGAGTAAGCGGAAGCCTTTTGTTGCGTCTTTTTGCATAGCACTCTTGTTAATGCTTGGTGCTCCTTTCTAGCCTCCTCTTGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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