Basic Information
VIS ID
TVIS44016005
Fusion event
HTLV-1-KY integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
134362095/134643253 (Hg38)
End
134362095/134643253 (Hg38)
Orient
-
Location type
Intronic
Target gene
KY
miRNAs that regulate target gene
hsa-mir-4309 ; hsa-mir-183-5p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-4663 ; hsa-mir-610 ; hsa-mir-4267 ; hsa-mir-7702 ; hsa-mir-6514-5p ; hsa-mir-874-3p ; hsa-mir-7158-3p ; hsa-mir-151a-3p ; hsa-mir-6799-3p ; hsa-mir-146b-3p ; hsa-mir-7976 ; hsa-mir-3173-5p ; hsa-mir-4539 ; hsa-mir-18a-3p ; hsa-mir-4463 ; hsa-mir-4499 ; hsa-mir-4724-5p
Nearest miRNA
hsa-let-7g/Upstream/205347; hsa-mir-1224/Downstream/16922623;
Nearest TSS
ENST00000440867/Upstream/15250; ENST00000497173/Downstream/7765;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/156656, chr3-CpG: 65/Downstream/7369
Upstream sequence
ATGAGACGCAGGGAGAGGAAAAGGGTTTTCCAACACCCATGGGAGCAGAGAGGACCCTGCTCCCCATAGTCTGAGCTCCACATCCTGGGCTGTCGCTGGC
Downstream sequence
CAGAGCATCAGGTCTGGGCACACCTCTGCAGGGGAGGTCACGGCTAGCGGCGAATCACTTACCTTGGCTGTTGTAGGAAGTGATGACCTGGGGCTGCTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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