Basic Information
VIS ID
TVIS44016008
Fusion event
HTLV-1-PPP2R3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
135705496/135986654 (Hg38)
End
135705496/135986654 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP2R3A
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-3117-3p ; hsa-mir-8083 ; hsa-mir-3169 ; hsa-mir-4759
Nearest miRNA
hsa-let-7g/Upstream/1548748; hsa-mir-1224/Downstream/15579222;
Nearest TSS
ENST00000440867/Upstream/20910; ENST00000447251/Downstream/36081;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/20129, chr3-CpG: 200/Downstream/208701
Upstream sequence
gatgactatttcttcagtctccttcatgttggatacctcctccccactcttcgctctcaactgatggcttgcttcctatttcaccaagaaactgagtcag
Downstream sequence
gaaggagctttatcaccacagctacccactacccgcagtagtatccatatactctgctttctttcctgttagtgtgaaagaactaccctaagtgctttat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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