Basic Information
VIS ID
TVIS44016010
Fusion event
HTLV-1-PIK3CB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
138440454/138721612 (Hg38)
End
138440454/138721612 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIK3CB
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-101-3p ; hsa-mir-125b-5p ; hsa-mir-1207-3p ; hsa-mir-4424 ; hsa-mir-4682 ; hsa-mir-6787-3p ; hsa-mir-6830-5p ; hsa-mir-8077 ; hsa-mir-130b-5p ; hsa-mir-2117 ; hsa-mir-3124-3p ; hsa-mir-4277 ; hsa-mir-4753-3p ; hsa-mir-6809-3p
Nearest miRNA
hsa-let-7g/Upstream/4283706; hsa-mir-1224/Downstream/12844264;
Nearest TSS
ENST00000440867/Upstream/6897; ENST00000498709/Downstream/21169;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/112269, chr3-CpG: 90/Downstream/112705
Upstream sequence
TATATATGTATATACACTTTGATCTTATTTGACTTTAAATgaacacaacaaagtctccactgcctaatctttcccaaatccagttttgaataaaaatatg
Downstream sequence
catacagaatttcctgaaaaacacacaacatttatttaggaagtccaaatattattcaattaaagataaaccatcaaatgggtgaatacagtactaagac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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