Basic Information
VIS ID
TVIS44016012
Fusion event
HTLV-1-CLSTN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
140050100/140331258 (Hg38)
End
140050100/140331258 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLSTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-3180-5p ; hsa-mir-3607-3p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-10b-3p ; hsa-mir-1343-5p ; hsa-mir-145-3p ; hsa-mir-1914-5p ; hsa-mir-3150a-3p ; hsa-mir-3175 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-5703 ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-6878-5p ; hsa-mir-7152-5p ; hsa-mir-939-5p
Nearest miRNA
hsa-let-7g/Upstream/5893352; hsa-mir-1224/Downstream/11234618;
Nearest TSS
ENST00000440867/Upstream/396071; ENST00000286349/Downstream/123473;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/394985, chr3-CpG: 37/Downstream/351359
Upstream sequence
tcccagagtccaaagtctgaagaatctggagtctgagtccaagggcagaaggacaggaagcaagcatctggcacgggaagagagagaaagaggactcggc
Downstream sequence
acgctgctcatctctcctcttccacctgcttttctacctgggctggcagctgatcagatggtgcctacccacaatgatggtggggcttccttgcacagtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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