Basic Information
VIS ID
TVIS44016014
Fusion event
HTLV-1-XRN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
142158907/142440065 (Hg38)
End
142158907/142440065 (Hg38)
Orient
+
Location type
Intronic
Target gene
XRN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-10a-5p ; hsa-let-7b-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4747-3p ; hsa-mir-1295b-3p ; hsa-mir-6507-5p ; hsa-mir-1277-5p ; hsa-mir-92b-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-let-7g/Upstream/8002159; hsa-mir-1224/Downstream/9125811;
Nearest TSS
ENST00000440867/Upstream/10291; ENST00000483373/Downstream/7927;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/214387, chr3-CpG: 71/Downstream/7295
Upstream sequence
caggagacgaaggtcctctgagacgaaggtctcaggagacgaaggtcctgctgaaccagatgatccagcagcaggactgagggtgcccggggaaagcgcc
Downstream sequence
agcccatgccatcaccctcacagagccctgggtatgctttaccactgagggccaggaggttaactgtctcctggacactggcacggccttctcagtctta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate