Basic Information
VIS ID
TVIS44016019
Fusion event
HTLV-1-GRIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
14582249/14540742 (Hg38)
End
14582249/14540742 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRIP2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12127/Upstream/4146180; hsa-let-7g/Downstream/955497;
Nearest TSS
ENST00000440867/Upstream/368; ENST00000635800/Downstream/1339;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/137673, chr3-CpG: 18/Downstream/15151
Nearby gene
GRIP2(-399) ;
Upstream sequence
ttccctcactaggcatcagttttttcatctggagacagggaacagtGCTTTCCAAACTTTTTTTTTTTCTAAACGGCAGATTCCAAGAGAATTTGCACAG
Downstream sequence
AACCCCAGGACATAAGCTAGATGAAGCACAGACTCTTTGACTGCATGAACAATGCCAGGGCGTCTCTGTAGGTCTCAGCTTAGAAACCCTTGAGCTTGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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