Basic Information
VIS ID
TVIS44016022
Fusion event
HTLV-1-IGSF10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
151204616/151486828 (Hg38)
End
151204616/151486828 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
IGSF10
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-548aw ; hsa-mir-578 ; hsa-mir-627-3p
Nearest miRNA
hsa-let-7g/Upstream/17048922; hsa-mir-1224/Downstream/79048;
Nearest TSS
ENST00000440867/Upstream/28119; ENST00000492731/Downstream/150346;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/399447, chr3-CpG: 92/Downstream/781710
Nearby gene
IGSF10(-28119) ;
Upstream sequence
aagacaagattagaataatgaaatgacagcagaaataaagatggtttttgaaaccaataagaacaaagacacaatgtaccagaatctctgggacagattt
Downstream sequence
aaagcagtgtgtagagggaaatttatagcactaaatgcccacaagcgaaagcatgaaagttctaaaattgatatcctaacatcataattagaagtactag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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