Basic Information
VIS ID
TVIS44016028
Fusion event
HTLV-1-ARHGEF26 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
153866256/154148467 (Hg38)
End
153866256/154148467 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
ARHGEF26
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-130a-3p ; hsa-mir-188-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-1260a ; hsa-mir-3121-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-4295 ; hsa-mir-4301 ; hsa-mir-3666 ; hsa-mir-4452 ; hsa-mir-3974 ; hsa-mir-4671-3p ; hsa-mir-3591-5p ; hsa-mir-4473 ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-3119 ; hsa-mir-216a-5p ; hsa-mir-216b-5p ; hsa-mir-22-3p ; hsa-mir-3679-3p ; hsa-mir-545-5p ; hsa-mir-548c-3p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-7705 ; hsa-mir-329-5p
Nearest miRNA
hsa-let-7g/Upstream/2582472; hsa-mir-1224/Downstream/5134179;
Nearest TSS
ENST00000440867/Upstream/27027; ENST00000483068/Downstream/77318;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/25876, chr3-CpG: 49/Downstream/280091
Upstream sequence
TTAGTGAAAGATTATAATTCTGTATATTAATACTTTACCTTTGTCAAAACTACCTTCTCTTTCCCCTCAAAAAAGCAAGTACTTTAGTTGTGGGTTTGCC
Downstream sequence
CTCTCTTTTGATAGGACAAAGTACTCTTAATTCCTCAGTAAAGTAGCTGTCATCTGTGTAGGTCGCTAAGCCCAGGTTTTTCATTCTCTTCTCCTTAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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