Basic Information
VIS ID
TVIS44016050
Fusion event
HTLV-1-KLHL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
183237592/183519804 (Hg38)
End
183237592/183519804 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
KLHL6
miRNAs that regulate target gene
hsa-mir-10a-5p
Nearest miRNA
hsa-let-7g/Upstream/7004653; hsa-mir-1224/Downstream/366996;
Nearest TSS
ENST00000440867/Upstream/91026; ENST00000491676/Downstream/24981;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/27649, chr3-CpG: 154/Downstream/115642
Upstream sequence
agagagactttgtctctaaaataataataataataataataaaaagccgggcatagtggtgcatggctatattcccagctacttgaaaggccaaggtagg
Downstream sequence
aaaatctcttgagcctgggagttcaaggctgcagtgagctatgattgtgccactgcactccagcctaggtgacacaccaaaaccctgtctcaaaaaaaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate