Basic Information
VIS ID
TVIS44016051
Fusion event
HTLV-1-SATB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
18481163/18439671 (Hg38)
End
18481163/18439671 (Hg38)
Orient
-
Location type
Intronic
Target gene
SATB1
miRNAs that regulate target gene
hsa-mir-448 ; hsa-mir-191-5p ; hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-296-3p ; hsa-mir-21-5p ; hsa-mir-567 ; hsa-mir-297 ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-8066 ; hsa-mir-8076 ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-129-5p ; hsa-mir-153-3p ; hsa-mir-2054 ; hsa-mir-759 ; hsa-mir-4797-5p ; hsa-mir-374c-5p ; hsa-mir-655-3p ; hsa-mir-574-5p ; hsa-mir-302c-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-3143 ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-223-5p ; hsa-mir-636 ; hsa-mir-581 ; hsa-mir-511-3p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-4417 ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12127/Upstream/1506411; hsa-let-7g/Downstream/875177;
Nearest TSS
ENST00000440867/Upstream/898; ENST00000475063/Downstream/5146;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/13499, chr3-CpG: 145/Downstream/3949
Nearby gene
SATB1(-898) ;
Nearest cancer related gene
SATB1(OG, No orient, 0)
Upstream sequence
CGATATATAAATTACTATAGTAGACACTTTTTCTTCAGTGTAGTGAAGGAGAACCTTATGTAACAGATTTGATTTATATGTTGTTATTAAGACCATATTC
Downstream sequence
TACCCTGATGTCAGTGGAATATGTGACTAGGTATTGATAACTGTGTATAGACAGTTAAGTGTAACCGCTTTTTAGATAATTTAAGTGAAAATAAGCCTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate