Basic Information
VIS ID
TVIS44016056
Fusion event
HTLV-1-ST6GAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
186758930/187041142 (Hg38)
End
186758930/187041142 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
ST6GAL1
miRNAs that regulate target gene
hsa-mir-492 ; hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-18a-3p ; hsa-mir-218-5p ; hsa-mir-8081 ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-526b-5p ; hsa-mir-924 ; hsa-mir-5009-3p
Nearest miRNA
hsa-let-7g/Upstream/254365; hsa-mir-28/Downstream/1647639;
Nearest TSS
ENST00000440867/Upstream/15659; ENST00000464827/Downstream/1874;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/109828, chr3-CpG: 63/Downstream/97997
Upstream sequence
CTCCACATGGCCCCCAGGCTGAGCTGCTGCTCTCCTGTCTCTGTTCAGAATACCTTCTGTGCCTTTTTGCTTATCTAGTTCAAATCCAATGAATACCATG
Downstream sequence
Ctcttgttttgccctcccaacactctgcaaatcacatagggcagagataattattctgaaaaactcaggggcagaaatattaagtgacctgcccaaggtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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