Basic Information
VIS ID
TVIS44016077
Fusion event
HTLV-1-C3orf35 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37425306/37383815 (Hg38)
End
37425306/37383815 (Hg38)
Orient
+
Location type
Intronic
Target gene
C3orf35
miRNAs that regulate target gene
hsa-mir-223-5p ; hsa-mir-4798-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-12127/Upstream/1639256; hsa-let-7g/Downstream/585589;
Nearest TSS
ENST00000440867/Upstream/56050; ENST00000422441/Downstream/68300;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/140025, chr3-CpG: 135/Downstream/68112
Nearby gene
C3orf35(No orient, 2454)
Upstream sequence
GATAAGTTTTTCTTTTGGGATTTGAGCCTCTTTGATTTGAAATTTAGCATAGGCCCAGAAGAAGACTCTGTCCTCTGAGTTTAATTTTTCCTAATCTCCT
Downstream sequence
GGAGAGGcagcattggctactagctaagagtacagcccctggggccaatgctatggagtgaatgtgtctcccaaaatttgtgtgttggaaacttaatccc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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