Basic Information
VIS ID
TVIS44016084
Fusion event
HTLV-1-ZKSCAN7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
44598929/44557437 (Hg38)
End
44598929/44557437 (Hg38)
Orient
-
Location type
Exonic
Target gene
ZKSCAN7
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7e-5p ; hsa-mir-3190-5p ; hsa-mir-340-3p ; hsa-mir-3926 ; hsa-mir-4684-5p ; hsa-mir-548s ; hsa-mir-6504-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-12127/Upstream/443127; hsa-let-7g/Downstream/304451;
Nearest TSS
ENST00000440867/Upstream/80; ENST00000468987/Downstream/8122;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1911, chr3-CpG: 27/Downstream/20944
Upstream sequence
GGTGCTTGAGCAGTTCCTGAGCATCCTCCCTGGGGAGCTCCGGACCTGGGTGCAGCTGCATCACCCTGAGAGTGGTGAGGAGGCTGTGGCTGTGGTGGAG
Downstream sequence
GATTTCCAGAGACACCTCAGTGGATCAGAGGAGGTGAGCAGTTGAGTCTAGAATGGCGGCCTGATGCTTCTCTAATGCTTGGGTTAGCCTAGGAATAGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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