VISDB Viral Integration Site DataBase

VIS ID

TVIS44016089

Fusion event

HTLV-1-CDC25A integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr3

Cytoband

p21.31

Reference genome

Start

End

48227352/48185862 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-15a-5p ; hsa-let-7c-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-34a-5p ; hsa-let-7b-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-193b-3p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-let-7i-5p ; hsa-mir-92a-3p ; hsa-mir-365a-3p ; hsa-mir-141-3p ; hsa-mir-584-3p ; hsa-mir-195-5p ; hsa-mir-497-5p ; hsa-mir-3138 ; hsa-mir-5693 ; hsa-mir-194-3p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-3120-3p ; hsa-mir-651-3p ; hsa-mir-4803 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-668-5p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-1281 ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-5584-3p ; hsa-mir-624-5p ; hsa-mir-4323 ; hsa-mir-140-3p ; hsa-mir-3121-3p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-26a-1-3p

Nearest miRNA

hsa-mir-12127/Upstream/336233; hsa-let-7g/Downstream/10702;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/96456, chr3-CpG: 111/Downstream/1725

Nearest cancer related gene

CDC25A(OG, No orient, 0)

Upstream sequence

GCCAGCTCAGATGACGCAGACCCACCCACCCATAGCTCATGTGTCTATACAGCCTTATGGAAAGTGAGGTGTTACAGCCCTTGCTCACCACACTGCTACA

Downstream sequence

AGTGATAATCCTATCCCCAGTTCTATATTAAATTACATTCTACATACAGAAGCCTACATTACATTTTAAGACTTGCTCTTGCAGTTCCTTTAACCTAAAG