Basic Information
VIS ID
TVIS44016099
Fusion event
HTLV-1-FHIT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
59747508/59761782 (Hg38)
End
59747508/59761782 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/3909188; hsa-mir-12124/Downstream/856023;
Nearest TSS
ENST00000440867/Upstream/251104; ENST00000475527/Downstream/252368;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/711564, chr3-CpG: 48/Downstream/1489150
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
tgcaacctctgtctcctgggtacaagtgattctcctgcctcacccttctcagtagctgggactacgggagtgcaccaccacacctggctagtttttgtag
Downstream sequence
agatggggtttcaccatgttggccaggctggtctcgaactcctgacctcatgacctgcccgcctcggcctcccaaagttctgggattgtaggtgtgagcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate