Basic Information
VIS ID
TVIS44016104
Fusion event
HTLV-1-CADPS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
62465270/62479595 (Hg38)
End
62465270/62479595 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
CADPS
miRNAs that regulate target gene
hsa-mir-5096 ; hsa-mir-377-3p ; hsa-mir-4643 ; hsa-mir-8485 ; hsa-mir-8064 ; hsa-mir-335-3p ; hsa-mir-561-3p
Nearest miRNA
hsa-let-7g/Upstream/1861725; hsa-mir-12124/Downstream/4745869;
Nearest TSS
ENST00000440867/Upstream/1272; ENST00000465262/Downstream/2260;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/100954, chr3-CpG: 127/Downstream/394347
Upstream sequence
GCCAGCTGCATTGAATTAATGCTTCAGAGAGAAATATAGCTAGTGCATAAATGCATACACAGCTACTGCAGGGCGGGGAGGGGGCACACGCCCAAGCATG
Downstream sequence
CTGAGAGGGAGCCTACGGCCTGGACCAACAGGGTAATGTTTTCAAGGACAGACCAGTCTGAGGTCAGTACGTAGACGTATCTGACACGATGGAGCAGGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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