Basic Information
VIS ID
TVIS44016111
Fusion event
HTLV-1-MAGI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
65408219/65422544 (Hg38)
End
65408219/65422544 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAGI1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-24-3p ; hsa-mir-324-3p
Nearest miRNA
hsa-let-7g/Upstream/4804674; hsa-mir-12124/Downstream/1802920;
Nearest TSS
ENST00000440867/Upstream/20840; ENST00000472514/Downstream/25693;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/42958, chr3-CpG: 69/Downstream/126465
Upstream sequence
ctgtgtgactgggGGGTGGTCAGTCTATTATAATGCTCACAACCTCAGAAAGTTCTCTCAGGATTAGCACTTATGAAATCAAAGGGTCCTGCATTAACTC
Downstream sequence
ATCTTttcattcaatgcagatgattttctgaatacctataatggactaggcaccattttaggcagcagggataaagtagtgattgcaaccaagtccctta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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