Basic Information
VIS ID
TVIS44016118
Fusion event
HTLV-1-FRMD4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
69529683/69480532 (Hg38)
End
69529683/69480532 (Hg38)
Orient
-
Location type
Intronic
Target gene
FRMD4B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-98-5p ; hsa-mir-3672 ; hsa-mir-4524a-3p ; hsa-mir-526b-5p ; hsa-mir-578 ; hsa-mir-6864-3p
Nearest miRNA
hsa-let-7g/Upstream/431497; hsa-mir-12124/Downstream/2061438;
Nearest TSS
ENST00000440867/Upstream/47403; ENST00000460597/Downstream/60808;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/94100, chr3-CpG: 108/Downstream/61328
Nearby gene
FRMD4B(-94228) ;
Upstream sequence
ccctcagctgccagtctgttggagtttgccagaggtccactccggacgctgtttgcctgggtatccgcagtggtggctgcagaacagcggattttcgtga
Downstream sequence
accgtgaaagctgctgtctgatcgttcctctggaagttttgtctcagaggaatacccggccgtgtgaggtgtcagtctgcccctactgggaggcgcctcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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