Basic Information
VIS ID
TVIS44016141
Fusion event
HTLV-1-OGG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
9817085/9775401 (Hg38)
End
9817085/9775401 (Hg38)
Orient
-
Location type
Intronic
Target gene
OGG1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-1260b ; hsa-mir-6824-5p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5092 ; hsa-mir-1178-5p ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-4790/Upstream/4525146; hsa-let-7g/Downstream/504950;
Nearest TSS
ENST00000440867/Upstream/5409; ENST00000479956/Downstream/12682;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/25074, chr3-CpG: 86/Downstream/16907
Nearby gene
TADA3(-4563) ;
Upstream sequence
agaaatcaccatgtgaaacttaatttccatttgctatcaaatgtatggagagtattttcaatgtatgattccagtttccACATGAGATATTACTGAAACA
Downstream sequence
GATTTTGGAGGACATCTACCAGTCTGCCACATTCCACATCTCACTTGTATTTCTTTGCACCAACTTCACCCTCACTCCCTCTCATTAGTCCAGCCTCTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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