Basic Information
VIS ID
TVIS44016154
Fusion event
HTLV-1-MCUB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
110556524/109635368 (Hg38)
End
110556524/109635368 (Hg38)
Orient
+
Location type
Intronic
Target gene
MCUB
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-324-3p
Nearest miRNA
hsa-mir-12113/Upstream/146573; hsa-mir-1243/Downstream/1225214;
Nearest TSS
ENST00000502981/Upstream/74378; ENST00000494604/Downstream/49072;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/74464, chr4-CpG: 76/Downstream/67435
Upstream sequence
gcatgtgtctttatagtagaatgatttataatcctttgggtatatacccagcacttagagccaggccagcaacctttaatatgcaaatgccaggcattag
Downstream sequence
aaactgggtccacccaaacgtggcagttcctgcggccttcttacccttgccccacgttcctggcaacatagccgcccccacatatccacgtgtgtaaaac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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