Basic Information
VIS ID
TVIS44016172
Fusion event
HTLV-1-JADE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q28.2
Reference genome
GRCh37/hg19
Start
129738344/128817189 (Hg38)
End
129738344/128817189 (Hg38)
Orient
-
Location type
Intronic
Target gene
JADE1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-145-5p ; hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-342-5p ; hsa-mir-324-3p ; hsa-mir-3934-3p ; hsa-mir-4427 ; hsa-mir-219b-3p ; hsa-mir-4680-3p ; hsa-mir-5010-3p ; hsa-mir-5187-3p ; hsa-mir-6854-5p ; hsa-mir-8068 ; hsa-mir-219a-2-3p
Nearest miRNA
hsa-mir-12113/Upstream/3309882; hsa-mir-1305/Downstream/14526271;
Nearest TSS
ENST00000502981/Upstream/5345; ENST00000508997/Downstream/14244;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/4359, chr4-CpG: 56/Downstream/276005
Upstream sequence
ctcaagtgacccacctacctcggcctcccaaagtgctagattacaggtgtgaaccaccatgactggccAGTTTTCTATTACTTTGAAAGCGCTCACAATT
Downstream sequence
GACATCTGTCtctttgtattttttgttagagagatgaggtttcactatgttgctcaggttgcccaggctagtcttgaactccagagctgagtcctcccgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate