Basic Information
VIS ID
TVIS44016186
Fusion event
HTLV-1-MAML3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
140701245/139780091 (Hg38)
End
140701245/139780091 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4C
Target gene
MAML3
miRNAs that regulate target gene
hsa-mir-3682-3p ; hsa-mir-4424 ; hsa-mir-4679 ; hsa-mir-1273g-3p ; hsa-mir-1272 ; hsa-mir-1255b-2-3p ; hsa-mir-4477b ; hsa-mir-5684 ; hsa-mir-651-3p ; hsa-mir-548c-3p ; hsa-mir-452-3p ; hsa-mir-576-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-499a-3p ; hsa-mir-499b-3p ; hsa-mir-505-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-664b-3p
Nearest miRNA
hsa-mir-12113/Upstream/14272784; hsa-mir-1305/Downstream/3563369;
Nearest TSS
ENST00000502981/Upstream/114063; ENST00000509184/Downstream/109961;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/44110, chr4-CpG: 35/Downstream/79761
Upstream sequence
TCGCCCCTAGGCCAGCAGATGCGCTGCCATTCCTGACTTCCAGTTCCTTATGAAGACCATGTAACCTAGAGCCATgctgtccgaggcggtacccactatt
Downstream sequence
tacatttaaatttaataaaattaaaaattcatttctgcaggcgtgtcagccacttttcaagtgttcatagccacacttggctagtggctactatattggg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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