Basic Information
VIS ID
TVIS44016198
Fusion event
HTLV-1-ARHGAP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
148690500/147769349 (Hg38)
End
148690500/147769349 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP10
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-12113/Upstream/424632; hsa-mir-1305/Downstream/13246;
Nearest TSS
ENST00000502981/Upstream/37286; ENST00000513548/Downstream/91634;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/36582, chr4-CpG: 294/Downstream/672711
Upstream sequence
CATCATGATCCTAATTACCACCAATGAAGGTAATTAGGGAAATTACTCAGTAAATGTTGTTGAGGAAGAAGGAAAAATGAAGGTATCCATCCATAACTCA
Downstream sequence
AGATGATCCCCTATTTAGAGAATAAGTATACATTCTACAGGCATCTAAGGTTTTCATGTTTCTCTGTTCTGTTTGGTTTTAATGGTATAATATACATTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate