Basic Information
VIS ID
TVIS44016208
Fusion event
HTLV-1-TMEM131L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154408439/153487287 (Hg38)
End
154408439/153487287 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM131L
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-335-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5007-3p ; hsa-mir-5092 ; hsa-mir-3163 ; hsa-mir-513b-3p ; hsa-mir-548n ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-606 ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4724-5p ; hsa-mir-216b-5p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-12113/Upstream/950771; hsa-mir-1305/Downstream/5641515;
Nearest TSS
ENST00000502981/Upstream/20938; ENST00000462540/Downstream/66894;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/19824, chr4-CpG: 95/Downstream/196647
Upstream sequence
TACTTTTTGTGGAGGATTAAATAATGAGAGGTAGAAATAGTCTTGTAGGTAAAACAGTGGGTGGAAATTGGGAGATGGTTGCTTTTCAGCCTGACTTACC
Downstream sequence
ACCACTGGCCCAGGATTTTATCAAACCTAGAATCCGTACGTATTCTCTTCATAGGGTATGGAGTGTTAGCTGGTGGATCGAGTGTGTCCGAAGAAGTTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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