Basic Information
VIS ID
TVIS44016213
Fusion event
HTLV-1-GUCY1A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
156620682/155699530 (Hg38)
End
156620682/155699530 (Hg38)
Orient
+
Location type
Intronic
Target gene
GUCY1A1
miRNAs that regulate target gene
hsa-mir-412-3p
Nearest miRNA
hsa-mir-12113/Upstream/3163014; hsa-mir-1305/Downstream/3429272;
Nearest TSS
ENST00000502981/Upstream/31867; ENST00000503520/Downstream/59462;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/31390, chr4-CpG: 119/Downstream/59413
Upstream sequence
ATAAAAAATTTAGTAGTCTATGTTGTTTGTTCATGAGTTTGTAAGAATAAGCATTAAGATTTGACTACAGTGTCATGTAACAGAGAGGGCAAGACTATAG
Downstream sequence
GAGATGGAAGAGGTATGTTTGGCATTAGTAACTAAAACTCCTCTCCAACTGAGATATTATCGTTATGGCAGTAAATGTTCCAGTGTTGAATACATTTGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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