Basic Information
VIS ID
TVIS44016222
Fusion event
HTLV-1-DDX60 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
169242702/168321551 (Hg38)
End
169242702/168321551 (Hg38)
Orient
-
Location type
Intronic
Target gene
DDX60
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12113/Upstream/2935214; hsa-mir-1305/Downstream/2864633;
Nearest TSS
ENST00000502981/Upstream/2744; ENST00000511948/Downstream/39888;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2878, chr4-CpG: 37/Downstream/158648
Nearby gene
DDX60(-2744) ;
Upstream sequence
GACCCAGTTAGGATCTCATCAAATGTATTATTTAACAACACAGCTGATACCTTTTTTTCTGTTCCCCTCAGCCTTCTGCATATTTCACAATGACAGTTAC
Downstream sequence
AATTCAGCACTTTACCATTCTCAAGTCTTTTAAATGATAGACCATCTCTTCTGTTTTCAAGGAGAATTCTCTCCAGCTTTCTGATAACTCCATATTCCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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