Basic Information
VIS ID
TVIS44016242
Fusion event
HTLV-1-SLIT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
20479403/20477780 (Hg38)
End
20479403/20477780 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
SLIT2
miRNAs that regulate target gene
hsa-mir-330-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12113/Upstream/6849823; hsa-mir-12115/Downstream/50495;
Nearest TSS
ENST00000502981/Upstream/222860; ENST00000509099/Downstream/55619;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/222535, chr4-CpG: 54/Downstream/222414
Nearest cancer related gene
SLIT2(TSG, No orient, 0)
Upstream sequence
GGTCAGCTGAAGGTCTGAAATAAACCACTTATGATACTTCTGCCCTTAGCATCCAACTGTCTTTAATGATCTGCAAATTTACACTATGTCTTAGTGAATA
Downstream sequence
GTTGGAGCATAATATTTTTTTTGAAGAAGTGAAAAAGTCTCCTCTGGCTATTTTCTTAATTCAGAATAATTTCGTAGCACAATTGCAAATCACATCTGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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